Genomic Sequencing Solutions

genomics lab Singapore with T10

Redefining Genomic Research Services

Advanced Sequencing Services

  • Complimentary Expert Design Review
  • High Quality Data
  • Customized Bioinformatics Analysis
  • Multi-platform Capabilities from MGI & Illumina

Flexible Options for any Genomics Project

  • Highly Competitive Pricing
  • Ultra-High Sequencing Capability

Your Trusted Partner

  • End to End Capabilities Based in Singapore
  • Certified Manufacturers Workflow
  • Compliant Data Protection and Data Privacy
Lab worker at MiRXES Genomic Lab

Human Whole Genome Sequencing

Human whole genome sequencing (hWGS) offers the ability to interrogate the entire genomic DNA sequences, providing a comprehensive characterization of the human genome.

MiRXES utilizes unique DNA nanoball sequencing technology coupled with PCR-free library preparation to deliver results with high accuracy and low sequencing artifacts. Sequence alignment and variant calling is provided complimentary with our hWGS services.

Service
Suggested Sequencing Depths
Sequencing Platforms
Human Whole Genome Sequencing
Rare Diseases: 30x (90Gb)
Oncology: ≥50x (≥150Gb)
DNBSEQ-T7
DNBSEQ-T10

Human Whole Exome Sequencing

Human whole exome sequencing (hWES) is a widely used genomic technique targeting protein-coding regions of the human genome, presenting as a cost-efficient alternative to hWGS that allows increased coverage of regions of interest.

In addition to traditional exome coverage, MiRXES Genomics hWES service also allows the choice of a large discovery panel that ensures the comprehensive capture of coding sequences related to various diseases e.g. reproductive, neonatal, cardiovascular and cerebrovascular, hereditary cancer, personal genome, immunodeficiency and 100% of the mitochondrial genome, or a focused exome purely on coding sequences with guaranteed >99% coverage. Variant calling based on best practices is provided complementary with every hWES service.

Service
Suggested Sequencing Depths
Sequencing Platforms
Human Whole Exome Sequencing
Rare Diseases: 100x (10Gb)
Oncology: ≥200x (≥20Gb)
DNBSEQ-T7

Human RNA Sequencing

RNA sequencing (RNASeq) is an indispensable tool for transcriptome-wide analysis of differential gene expression and structural analysis of RNAs.

MiRXES Genomics offers an efficient package for rRNA depletion with synthesis of cDNA libraries from a wide input range of total RNA. These libraries are then sequenced on using DNBseq technology, generating high quality data for comprehensive analysis of gene expression analysis and discovery of alternate splicing events, gene fusions and other transcriptome aberrations.

 

Service
Suggested Sequencing Depths
Sequencing Platforms
Human RNA Sequencing
≥40M reads (≥12Gb)
≥60M reads (≥18Gb)
DNBSEQ-T7

Human Whole Genome Bisulphite Sequencing

Human whole genome bisulphite sequencing (hWGBS) offers the ability to interrogate methylation status at a single base resolution epigenome-wide. It has become an increasingly accessible technique to investigate changes in methylation patterns associated with complex diseases including cancer and neurological disorders.

Equipped with the largest sequencers in the world, MiRXES Genomics enables high-throughput methylation analysis by revolutionizing the cost of sequencing and providing end-to-end bioinformatics support for large datasets.

Service
Suggested Sequencing Depths
Sequencing Platforms
Human Whole Genome Bisulphite Sequencing
Basic analysis: 30x (90Gb)
Deep analysis: 100x (300Gb)
DNBSEQ-T7
DNBSEQ-T10

Sequencing Only Service

With a variety of high-throughput sequencing platforms, MiRXES Genomics provides standalone next generation sequencing service to researchers preparing their own libraries. We work with strict quality controls and optimized sequencing workflows to deliver high quality data for your research.

MiRXES Genomics can accept premade libraries for sequencing on multiple platforms including MGI’s T7 and T10, and Illumina’s NovaSeq6000.

Platforms
Sequencing Read Lengths
Purchase UOM
MGI T7
PE100, PE150
Flow cells/Full run
MGI T10
PE100, PE150
Flow cells/Full run
Illumina NovaSeq 6000
PE150
Lanes/Flow cells

MiRXES Genomics Bioinformatics Service

Standard Analysis Package

  • Data QC: filtering reads with adapter or low-quality sequence data
  • Alignment to reference genome using BWA
  • Summary statistics of sequencing depth and coverage
  • Germline variant calling based on best practices
  • Somatic variant calling based on best practices (for tumor alone and/or tumor-normal paired samples) 

Additional Bioinformatics Services*

    • Population Studies
    • Variant Analysis
    • Gene Expression Data Analysis
    • Methylation Analysis
    • Data Integration Service
    • Single Cell Analysis Service

*Additional charges will apply

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