Tested and proven testing solutions
MiRXES offers complete COVID-19 testing solutions, starting from sample collection and preservation, through easy and reliable RNA extraction, to tested and proven SARS-CoV-2 RT-PCR diagnostic tests and mutation panels for quick identification of key variants.
Sample Collection & Processing Solutions
November 2021 Update: SARS-CoV-2 Variants
The World Health Organization (WHO) has defined a SARS-CoV-2 isolate as a variant of interest (VOI) if it is phenotypically changed compared to a reference isolate of has a genome with mutations that lead to amino acid changes associated with established or suspected phenotypic implications; AND has been identified to cause community transmission/multiple COVID-19 cases/clusters, or has been detected in multiple countries.
A VOI is further classified as a variant of concern (VOC) if, through a comparative assessment, it has been demonstrated to be associated with:
- Increase in transmissibility of detrimental change in COVID-19 epidemiology;
- Increase in virulence or change in clinical disease presentation; or
- Decrease in effectiveness of public health and social measures or available diagnostics, vaccines, therapeutics.
WHO-designated SARS-CoV-2 variants of concern (VOCs), as of 29 November 2021.
Spike protein substitutions
N501Y, 69del, 70del, 144del, (E484K*), (S494P*), N501Y, A570D, D614G, P681H, T716I, S982A, D1118H (K1191N*)
D80A, D215G, 241del, 242del, 243del, K417N, E484K, N501Y, D614G, A701V
L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I
T19R, (V70F*), T95I, G142D, E156-, F157-, R158G, (A222V*), (W258L*), (K417N*), L452R, T478K, D614G, P681R, D950N
WHO-designated SARS-CoV-2 variants of interest (VOIs), as of 29 November 2021.
Spike protein substitutions
S13I, W152C, L452R, D614G
A67V, 69del, 70del, 144del, E484K, D614G, Q677H, F888L
US (New York)
L5F, (D80G*), T95I, (Y144-*), (F157S*), D253G, (L452R*), (S477N*), E484K, D614G, A701V, (T859N*), (D950H*), (Q957R*)
(T95I), G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
T19R, G142D, L452R, E484Q, D614G, P681R, D950N
G75V, T76I, 246-252del, L452Q, F490S, D614G, T859N
E484K, N501Y, P681H
Detection of key SARS-CoV-2 variants by MiRXES RT-PCR test kits
The MiRXES R&D team is constantly tracking the World Health Organization’s designation of new VOCs and VOIs and has performed in silico analyses to determine the sequence homology between the MiRXES SARS-CoV2 RT-PCR primers and all SARS-CoV-2 sequences, including those of specific variants.
Overall, >99.4% of aligned sequences have 100% homology to either the ORF or N gene target sequence of MiRXES RT-PCR test kits.
Percentage of aligned sequences in the GISAID database that have 100% homology to the primer (probe) sequence of the MiRXES RT-PCR test kits, as of 29 November 2021:
Sequence homology with
Fortitude Syndromic Panel
All SARS-CoV-2 ORF target sequences
All SARS-CoV-2 N gene target sequences