Key Scientific Publications
Author(s): Zou R, Loke SY, Tan VKM, Quek ST, Jagmohan P, Tang YC, Madhukumar P, Tan BKT, Yong WS, Sim Y, Lim SZ, Png E, Lee SYS, Chan MYP, Ho TSJ, Khoo BKJ, Wong SLJ, Thng CH, Chong BK, Teo YY, Too HP, Hartman M, Tan NC, Tan EY, Lee SC, Zhou L, and Lee ASG. Cancers 2021; 13(9), 2130
Summary: Mammography is extensively used for breast cancer screening but has high false-positive rates. This paper describes the discovery, development, and validation of a serum 6-miRNA panel to discriminate between malignant and benign breast lesions among women with abnormal mammograms.
Author(s): Hong LZ, Zhou L, Zou R, Khoo CM, Chew ALS, Chin C-L & Shih S-J. Scientific Reports 2021; 11:4435
Summary: Cross-platform evaluation study led by Merck (MSD) scientists showing that MiRXES ID3EAL miRNA qPCR platform has superior reproducibility and detection rate compared to other commercial miRNA profiling platforms (Exiqon qPCR, Qiagen qPCR, Applied Biosystems qPCR, NanoString nCounter, and miRNA-Seq) when used for discovery and validation of blood-based miRNA biomarkers.
Author(s): So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lee J, Lam K-P, Hartman M, Yong WP, Too HP, Yeoh KG. Gut 2020 Oct
Summary: Discovery, development, and large-scale prospective clinical validation of GASTROClear – a serum 12-miRNA biomarker panel for early detection of gastric cancer. The panel was validated to detect 87% of all gastric cancer patients, including 87.5% of Stage 1 tumours.
Author(s): Ying L, Du L, Zou R, Shi L, Zhang N, Jin J, Xu C, Zhang F, Zhu C, Wu J, Chen K, Huang M, Wu Y, Zhang Y, Zheng W, Pan X, Chen B, Lin A, Tam JKC, van Dam RM, Lai DTM, Chia KS, Zhou L, Too HP, Yu H, Mao W, Su D. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2020 Sep
Summary: Discovery, development, and validation of a serum 5-miRNA biomarker panel for early detection of non-small call lung cancer (NSCLC). The panel was validated to detect 81.3% of all NSCLC patients, including 83.0% of Stage 1 tumours.
Author(s): Wan G, Lim QE, Too HP. RNA 2010 Jul;16(7):1436-45.
Summary: Paper describing the development of a high-performance real-time RT-PCR assay that allows specific and rapid quantification of existing and novel miRNAs using a fast thermocycling profile. The assay had a wide dynamic range (more than 7 orders of magnitude) and was capable of detecting miRNAs from as little as 1 picogram of total RNA (or as few as 10 cells).
Other Scientific Journal Papers
Author(s): Lam ATL, Lee AP, Jayaraman P, Tan KY, Raghothaman D, Lim HL, Cheng H, Zhou L, Tan AHM, Reuveny S, Oh S . Stem Cells Research 2021 Feb 26;53:102272.
Author(s): Low SYY, Cheng H, Zou R, Ng LP, Kuick CH, Sulaiman NBS, Chang KTE, Low DCY, Zhou L, Seow WT. BMC Neurology 2020; 20:415
Author(s): Kapoor R, So JBY, Zhu F, Too HP, Yeoh KG, Yoong JSY. Value in Health 2020 Sep;23(9):1171-1179.
Author(s): Chung KY, Quek JM, Neo SH, Too HP. J Mol Diagn 2020 May;22(5):610-618.
Author(s): Choi H, Koh HWL, Zhou L, Cheng H, Loh TP, Parvaresh Rizi E, Toh SA, Ronnett GV, Huang BE, Khoo CM. Frontiers in Physiology 2019 Apr 5;10:379
Author(s): Wong LL, Zou R, Zhou L, Lim JY, Phua DCY, Liu C, Chong JPC, Ng JYX, Liew OW, Chan SP, Chen YT, Chan MMY, Yeo PSD, Ng TP, Ling LH, Sim D, Leong KTG, Ong HY, Jaufeerally F, Wong R, Chai P, Low AF, Lund M, Devlin G, Troughton R, Cameron VA, Doughty RN, Lam CSP, Too HP, Richards AM. Journal of the American College of Cardiology 2019 Mar 26;73(11):1300-1313
Author(s): Saw WY, Tantoso E, Begum H, Zhou L, Zou R, Cheng H, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY. Nature Communications 2017 Sep 21;8(1):653.
Author(s): Ho YK, Xu WT, Too HP. PLoS One 2013 Sep 5;8(9):e72463.
Author(s): Yoong LF, Wan G, Too HP. Journal of Neurochemistry, August 2006
Scientific Conference Presentations/Posters
Author(s): Waxman A, Fong Y, Jatkoe T, Cheng H, Zhou L, Bridges C. (European Respiratory Society International Congress, September 2020)
Author(s): Lawrie A, Toshner M, Fong Y, Jatkoe T, Cheng H, Zhou L, Bridges C, Howard LS, Wilkins MR. American Journal of Respiratory and Critical Care Medicine 2020;201:A6352 (American Thoracic Society International Conference, May 2020)
Author(s): So BYJ, Zhou L, Zou R, Zhu F, Koh CJ, Rha SY, Chung HC, Rao J, Chia CK, Tsao S, Shabbir A, Yong WP, Too HP, Yeoh KG. United European Gastroenterology Journal Volume 7 Issue 8 (Supplement), October 2019 (United European Gastroenterology Week 2019 Meeting – Presentation)
Author(s): Zhou L, So J, Kapoor R, Zhu F, Zou R, Koh CJ, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lam KP, Hartman M, Yong WP, Too HP, Yeoh KG. Journal of Clinical Oncology 2019 (American Society for Clinical Oncology 2019 Meeting)
Author(s): Zou R, Zhou L, Loke SY, Too HP, Lee A. Journal of Clinical Oncology 2019 37:suppl, 3051 (American Society for Clinical Oncology 2019 Meeting)
Author(s): Ying L, Zou R, Du L, Shi L, Zhang N, Jin J, Wu J, Zhang F, Chen K, Yu H, Mao W, Su D. Cancer Research 2018;78(13 Suppl):4408 (American Association for Cancer Research 2018 Meeting)
Author(s): So J, Zou R, Zhou L, Too HP, Zhu F, Teo YY, Yap CT, Rha SY, Kono K, Yoong J, Yeoh KG, Yong WP. Journal of Clinical Oncology 2015 33:15_suppl, 4060-4060 (American Society for Clinical Oncology 2015 Meeting)
Author(s): Wong LL, Lim JY, Zhou L, Zou R, Chan MMY, Lam CSP, Too HP, Richards AM. Circulation 2014 130:A15048 (American Heart Association 2014 Meeting)
Author(s): Zhou L, So JB, Zou R, Feng Z, Yong WP, Teo YY, Chia KS, Yap CT, Kono K, Too HP, Yeoh KG. Gastroenterology 2014 Volume 146, Issue 5, S-31 (American Gastroenterological Association 2014 Meeting)