Author(s): Cheong JK, Tang YC, Zhou LH, Cheng H, and Too HP. Current Opinion in Biotechnology 2022 Jan 6; 74:256–262

Key to the delivery of preventive healthcare is the clinical adoption of novel assays that enable early disease detection. This review article discusses the clinical utility and validation of miRNA-based molecular diagnostics for early disease detection through large-cohort studies and key considerations for developing multi-analyte clinical assays. 

Author(s): Zou R, Loke SY, Tang YC, Too HP, Zhou L, Lee ASG, and Hartman M. British Journal of Cancer 2022 Jan 10

This paper describes the largest comprehensive, multi-center study to date involving diverse ethnic groups, for the identification of circulating miRNAs for breast cancer screening. The panel detects breast cancer in Caucasian and Asian populations, including pre-malignant lesions (stage 0) and early-stage (stages 1-2) cancers.

Author(s): Zou R, Loke SY, Tan VKM, Quek ST, Jagmohan P, Tang YC, Madhukumar P, Tan BKT, Yong WS, Sim Y, Lim SZ, Png E, Lee SYS, Chan MYP, Ho TSJ, Khoo BKJ, Wong SLJ, Thng CH, Chong BK, Teo YY, Too HP, Hartman M, Tan NC, Tan EY, Lee SC, Zhou L, and Lee ASG. Cancers 2021 Apr 28;13(9):2130

Mammography is extensively used for breast cancer screening but has high false-positive rates. This paper describes the discovery, development, and validation of a serum 6-miRNA panel to discriminate between malignant and benign breast lesions among women with abnormal mammograms. 

Author(s): So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lee J, Lam K-P, Hartman M, Yong WP, Too HP, Yeoh KG. Gut 2021 May; 70(5):829-837. Epub 2020 Oct 7.

Discovery, development, and large-scale prospective clinical validation of  GASTROClear – a serum 12-miRNA biomarker panel for early detection of gastric cancer. The panel was validated to detect 87% of all gastric cancer patients, including 87.5% of Stage 1 tumours.

Author(s): Ying L, Du L, Zou R, Shi L, Zhang N, Jin J, Xu C, Zhang F, Zhu C, Wu J, Chen K, Huang M, Wu Y, Zhang Y, Zheng W, Pan X, Chen B, Lin A, Tam JKC, van Dam RM, Lai DTM, Chia KS, Zhou L, Too HP, Yu H, Mao W, Su D. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2020 Oct 6;117(40):25036-25042  

Discovery, development, and validation of  a serum 5-miRNA biomarker panel for early detection of non-small call lung cancer (NSCLC). The panel was validated to detect 81.3% of all NSCLC patients, including 83.0% of Stage 1 tumours.

Author(s): Wan G, Lim QE, Too HPRNA 2010 Jul;16(7):1436-45. 

Paper describing the development of a high-performance real-time RT-PCR assay that allows specific and rapid quantification of existing and novel miRNAs using a fast thermocycling profile. The assay had a wide dynamic range (more than 7 orders of magnitude) and was capable of detecting miRNAs from as little as 1 picogram of total RNA (or as few as 10 cells).

Author(s): Lam ATL, Lee AP, Jayaraman P, Tan KY, Raghothaman D, Lim HL, Cheng H, Zhou L, Tan AHM, Reuveny S, Oh S . Stem Cells Research 2021 Feb 26;53:102272.

Author(s): Low SYY, Cheng H, Zou R, Ng LP, Kuick CH, Sulaiman NBS, Chang KTE, Low DCY, Zhou L, Seow WT. BMC Neurology 2020; 20:415

Author(s): Choi H, Koh HWL, Zhou LCheng H, Loh TP, Parvaresh Rizi E, Toh SA, Ronnett GV, Huang BE, Khoo CM. Frontiers in Physiology 2019 Apr 5;10:379

Author(s): Wong LL, Zou RZhou L, Lim JY, Phua DCY, Liu C, Chong JPC, Ng JYX, Liew OW, Chan SP, Chen YT, Chan MMY, Yeo PSD, Ng TP, Ling LH, Sim D, Leong KTG, Ong HY, Jaufeerally F, Wong R, Chai P, Low AF, Lund M, Devlin G, Troughton R, Cameron VA, Doughty RN, Lam CSP, Too HP, Richards AM. Journal of the American College of Cardiology 2019 Mar 26;73(11):1300-1313

Author(s): Neo SHChung KYQuek JMToo HP. Scientific Reports 2017 Nov 30;7(1):16686.

Author(s): Saw WY, Tantoso E, Begum H, Zhou LZou RCheng H, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY. Nature Communications 2017 Sep 21;8(1):653.

Author(s): Cheng HZhou L, Li B, Zhu M, Too HP, Choi WK. Nanomedicine 2014 Nov;10(8):1871-5. 

Author(s): Low SY, Ho YKToo HP, Yap CT, Ng WH. Journal of Clinical Neuroscience 2014 Mar;21(3):395-400.

Author(s): Waxman A, Fong Y, Jatkoe T, Cheng H, Zhou L, Bridges C.  (European Respiratory Society International Congress, September 2020)

Author(s): Lawrie A, Toshner M, Fong Y, Jatkoe T, Cheng H, Zhou L, Bridges C, Howard LS, Wilkins MR. American Journal of Respiratory and Critical Care Medicine 2020;201:A6352 (American Thoracic Society International Conference, May 2020)

Author(s):  So BYJ, Zhou L, Zou R,  Zhu F, Koh CJ, Rha SY, Chung HC, Rao J, Chia CK, Tsao S, Shabbir A, Yong WP, Too HP, Yeoh KG. United European Gastroenterology Journal Volume 7 Issue 8 (Supplement), October 2019 (United European Gastroenterology Week 2019 Meeting – Presentation)

Author(s):  Zhou L, So J, Kapoor R, Zhu F, Zou R, Koh CJ, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lam KP, Hartman M, Yong WP, Too HP, Yeoh KG. Journal of Clinical Oncology 2019 (American Society for Clinical Oncology 2019 Meeting)

Author(s): Zou RZhou L, Loke SY, Too HP, Lee A. Journal of Clinical Oncology 2019 37:suppl, 3051 (American Society for Clinical Oncology 2019 Meeting)

Author(s): Ying L, Zou R, Du L, Shi L, Zhang N, Jin J, Wu J, Zhang F, Chen K, Yu H, Mao W, Su D. Cancer Research 2018;78(13 Suppl):4408 (American Association for Cancer Research 2018 Meeting)

Author(s): So J, Zou RZhou LToo HP, Zhu F, Teo YY, Yap CT, Rha SY, Kono K, Yoong J, Yeoh KG, Yong WP. Journal of Clinical Oncology 2015 33:15_suppl, 4060-4060 (American Society for Clinical Oncology 2015 Meeting)

Author(s): Wong LL, Lim JY, Zhou LZou R, Chan MMY, Lam CSP, Too HP, Richards AM. Circulation 2014 130:A15048 (American Heart Association 2014 Meeting)

Author(s): Zhou L, So JB, Zou R, Feng Z, Yong WP, Teo YY, Chia KS, Yap CT, Kono K, Too HP, Yeoh KG. Gastroenterology 2014 Volume 146, Issue 5, S-31 (American Gastroenterological Association 2014 Meeting)

Copyright © 2022 MiRXES Pte Ltd. All rights reserved. | Privacy Policy
Scroll to Top