MiRXES Welcomes Genomics Expert to Scientific Advisory Board

MiRXES Welcomes Genomics Expert to Scientific Advisory Board

Dr Holger Heyn, an expert in single-cell genomics and spatial transcriptomics, has joined the Scientific Advisory Board of MiRXES to help advance its development of RNA-powered multi-omics solutions for research and diagnostics.   

Prof Holger Heyn
Dr Holger Heyn, MiRXES Scientific Advisory Board member

SINGAPORE, 28 July 2021 – MiRXES Pte Ltd, a biotechnology company focused on improving and saving lives with RNA-powered disease early detection tests, announced today the appointment of Dr Holger Heyn, an expert in single-cell genomics and spatial transcriptomics, as a Scientific Advisory Board (SAB) member. The addition of Dr Heyn to the MiRXES SAB will strengthen the company’s scientific expertise in the areas of transcriptomics, epigenomics, and genomics, thus accelerating its development of RNA-powered multi-omics solutions for research and diagnostics.

Dr Heyn is the Leader of the Single Cell Genomics Team at the Spanish National Centre for Genomic Analysis (CNAG-CRG) in Barcelona, Spain. His group is at the forefront of genome research, applying single-cell (spatial) transcriptomics, epigenomics and genomics techniques to immuno-oncology research and Human Cell Atlas (HCA) projects. The HCA seeks to describe the cellular basis of the healthy human system as a reference to pinpoint cell types and alterations driving diseases. Dr Heyn co-chairs the Standards and Technology working group of the HCA, leads the atlas of the B-cell lineage and contributes to the atlases of the pancreas and kidney. He has authored 77 publications with a total of more than 10,000 citations (with a H-index of 46) and has previously contributed to the European Epigenome (BLUEPRINT) and The Cancer Genome Atlas (TCGA) projects.

“I am absolutely delighted to join the MiRXES SAB. I look forward to working together with the other SAB members and MiRXES management to push the boundaries of high-resolution diagnostics and fulfil our joint goal to further personalize medicine,” said Dr Heyn, who is also scientific co-founder of Omniscope, a systems diagnostics company that reads the immune system to detect diseases early and monitor patients’ health over time.  

“We are honored to welcome Dr Holger Heyn to our SAB. His expertise in the exciting new genomic research frontiers of single-cell genomics and spatial transcriptomics is a significant addition to the knowledge base of our SAB which include internationally-recognized experts in the areas of RNA biology, oncology, liquid biopsy, and molecular pathology,” said Dr Lihan ZHOU, Co-founder and CEO of MiRXES. 

More information on the MiRXES SAB here: https://mirxes.com/scientific-advisory-board/

About MiRXES

Founded in 2014 as a spin-off from Singapore’s Agency for Science, Technology, and Research (A*STAR) with strong support from the National University of Singapore (NUS), MiRXES is a leading developer of RNA-powered tests for disease early detection, with strong pipelines in multiple cancer types, as well as in cardiovascular, metabolic and infectious diseases. MiRXES is headquartered in Singapore, with operations in China, Japan and the United States, as well as commercial activities in over 45 countries globally. In 2019, MiRXES launched GASTROClear, the world’s first microRNA blood test for early detection of gastric cancer. The MiRXES’s multi-cancer early detection pipeline includes screening tests for lung, colorectal, liver, and breast cancer. In response to the COVID-19 pandemic in 2020, MiRXES worked closely with A*STAR, Diagnostics Development Hub (DxD) and Tan Tock Seng Hospital (TTSH) to mass produce Fortitude Kit, Singapore’s first authorised COVID-19 RT-PCR test. Since February 2020, more than 7 million Fortitude Kits have been deployed globally.

For more information, visit www.mirxes.com

Follow us on LinkedIn @ https://www.linkedin.com/company/mirxes/

 

MiRXES Secures US$77 Million Series C Funding To Accelerate Multi-Cancer Early Detection Pipeline With Overwhelming Investor Support

MiRXES Secures US$77 Million Series C Funding To Accelerate Multi-Cancer Early Detection Pipeline With Overwhelming Investor Support

Led by CR-CP Life Science Fund, this new capital will support MiRXES’s growth as a global leader in cancer early detection tests and preventive healthcare

MiRXES team in action

SINGAPORE, 8 July 2021 – MiRXES Pte Ltd, a biotechnology company focused on improving and saving lives with RNA-powered disease early detection tests, announced today it has raised US$77 million in Series C funding to accelerate its push to deliver cancer early detection tests and preventive healthcare globally. This brings the total amount secured by MiRXES since its inception in 2014 to US$120 million, which marks the largest funding to date raised by a Singapore-headquartered cancer diagnostics company. This Series C funding is led by CR-CP Life Science Fund, joined by global healthcare investment firm Rock Springs Capital and Singapore-based global investor EDBI, and established financial institutions from the United States, Singapore, China and Hong Kong including, among others, CCBI and Keytone Ventures.

Commenting on this new financing round, Dr Lihan ZHOU, Co-founder and Chief Executive Officer of MiRXES said, “We are honored by the overwhelming support from our investors who have placed their trust and confidence in the value of our science and the potential of our business. With this fresh funding, MiRXES will bring forward our plans to deliver a comprehensive portfolio of non-invasive screening tests for early detection of six major cancers, and to expand the use of our platform RNA technology for cardiovascular, metabolic and infectious diseases research and diagnostics globally.”

The new investment will be used primarily to fund the development and commercialization of MiRXES’s pipeline of multi-cancer early detection tests that look for blood borne microRNA and other molecular signatures released by cancer and immune cells. MiRXES currently collaborates with leading academic and clinical institutions in Singapore, the United States, China, Italy and Japan to conduct large-scale clinical studies on lung, colorectal, liver, breast, pancreatic cancers with total enrolment of more than 30,000 participants.

MiRXES is also using the new funding to accelerate regulatory approval and adoption of GASTROClear, the world’s first RNA-powered blood test for the early detection of gastric cancer, in China, Japan and selected countries in Asia, Europe and Americas that have high rates of gastric cancer. Most immediately, MiRXES’s China operation is launching a 12,000- strong prospective clinical trial to seek registration of GASTROClear as a screening test with China’s National Medical Products Administration. In markets where GASTROClear is approved, MiRXES is working with healthcare, insurance and laboratory partners to enable greater accessibility [1] of GASTROClear to populations at-risk of developing gastric cancer. 

In anticipation of the growth, MiRXES is doubling its global talent pool to 400 staff over the next two years with significant build up in R&D, data science and commercial teams in major markets.

Dr Zhou added, “Biotechnology is rapidly transforming the way we think about health and wellness. At MiRXES, we believe that prevention is better than cure, and early detection will deliver major clinical and socio-economical impact as our populations age. Preventive healthcare is catching on globally, made possible by innovative biotechnology solutions such as GASTROClear, our flagship diagnostic product. We are excited that like-minded investors and partners globally have joined us in our journey to improve and save lives through early disease detection.”

Mr Da LIU, Managing Director, CR-CP Life Science Fund said, “MiRXES’s unique RNA technology as well as the founder management team’s passion and strong track record in developing and commercializing novel RNA-based clinical diagnostic tests have established MiRXES as a leader in cancer early detection tests. MiRXES’s best-in-class technology, differentiated business model, and strategic advantage with its headquarter in Singapore and infrastructures in major markets offer MiRXES a strong competitive advantage to access markets in Asia Pacific and globally. We are delighted to lead this financing round and are confident that our operational resources will be able to accelerate MiRXES’s growth in China, as well as assist MiRXES to realize their ambition of becoming a global leader in RNA-powered diagnostics and preventive medicine.”

Ms Swee Yeok CHU, CEO and President of EDBI said, “MiRXES has consistently built diagnostic capabilities in Singapore, and played an important role in successfully mass-producing and deploying COVID-19 PCR test kits (Fortitude Kit) to over 45 countries. The team’s continued innovation in developing RNA-powered early detection solutions for cancers and other diseases, and enduring partnerships with local research institutes and healthcare institutions, embodies its commitment and contribution to advancing the biomedical ecosystem.”

Mr Jay KRASKA, Analyst, Rock Springs Capital said, “MiRXES’s unique PCR-based platform’s ability to accurately and robustly detect RNA biomarkers from biological fluids like blood and urine has opened up a pathway of possibilities towards preventive healthcare and precision medicine. We are excited about MiRXES’s future and look forward to supporting the MiRXES team as they accelerate their clinical development in Asia, the United States, and worldwide.”

[1] GASTROClear test can be ordered by healthcare providers through MiRXES partner diagnostic labs such as Innovative Diagnostics, ParkwayHealth Laboratory, Tan Tock Seng Hospital Molecular Diagnostic Lab and National University Hospital Molecular Diagnostic Centre.

About MiRXES

Founded in 2014 as a spin-off from Singapore’s Agency for Science, Technology, and Research (A*STAR) with strong support from the National University of Singapore (NUS), MiRXES is a leading developer of RNA-powered tests for disease early detection, with strong pipelines in multiple cancer types, as well as in cardiovascular, metabolic and infectious diseases. MiRXES is headquartered in Singapore, with operations in China, Japan and the United States, as well as commercial activities in over 45 countries globally. In 2019, MiRXES launched GASTROClear, the world’s first microRNA blood test for early detection of gastric cancer. The MiRXES’s multi-cancer early detection pipeline includes screening tests for lung, colorectal, liver, and breast cancer. In response to the COVID-19 pandemic in 2020, MiRXES worked closely with A*STAR, Diagnostics Development Hub (DxD) and Tan Tock Seng Hospital (TTSH) to mass produce Fortitude Kit, Singapore’s first authorised COVID-19 RT-PCR test. Since February 2020, more than 7 million Fortitude Kits have been deployed globally.

 

For more information, visit www.mirxes.com

Follow us on LinkedIn @ https://www.linkedin.com/company/mirxes/

 

 

About CR-CP Life Science Fund

CR-CP Life Science Fund is a joint venture set up by China Resources Group and Charoen Pokphand Group, one of the largest private Thai conglomerates. The fund is mandated to invest in leading life science companies that develop innovative drugs and therapies, medical technology and smart healthcare technology.

 

 

About China Resources Group

China Resources Group is a Hong Kong based conglomerate and it ranked 79th of the Fortune Global 500 enterprises in 2020.

 

 

About Charoen Pokphand Group

Charoen Pokphand Group (“CP”) is a Thai based conglomerate. Together with its subsidiaries, CP operates across many industries ranging from industrial to services sectors, which are categorized into 8 business lines covering 13 business groups including agro-industrial and food, retail and distribution, media and telecommunications, information and communications technology, property development, automotive and industrial products, pharmaceuticals and finance.

 

 

About EDBI

Investing since 1991, EDBI is a Singapore-based global investor in select high growth technology sectors ranging from Information & Communication Technology (ICT), Emerging Technology (ET), Healthcare (HC) and promising Singapore-based companies in strategic industries. As a value creating investor, EDBI assists companies achieve their ambitious goals by leveraging our broad network, resources and expertise. With our growth capital, EDBI supports companies seeking to expand in Asia and globally through Singapore. For more information, visit https://www.edbi.com

 

 

About Rock Springs Capital

Rock Springs Capital is an investment advisory firm that pursues an investment strategy focused primarily on investing in companies in the healthcare and healthcare related industries.  The investment activities of Rock Springs Capital are led by a team of well-known healthcare industry investors with significant experience investing together.